![]() ![]() Among the studies he conducted beginning in the early 1930s, the examination of the ratio of potassium isotopes 39K/41K in a wide range of living and nonliving materials proved most fruitful, particularly in the study of cancer initiation. Keith Brewer, a physicist, served for some time in his research career as Chief of the Mass Spectrometer and Isotope section of the National Bureau of Standards (now the National Institute of Standards and Technology, Gaithersburg, MD). Reflections on the Unexplored Work of a Perceptive ResearcherÄr.Tests on mice fed cesium and rubidium showed marked shrinkage in the tumor masses within 2 weeks. ![]() Where cell mitosis ceases and the life of the cell is short. Mass spectrographic and isotope studies have shown that potassium, rubidium, and especially cesium are most efficiently taken up by cancer cells. The High pH Therapy for Cancer Tests on Mice and Humans.The development of his theory of the High pH Cancer Therapy with Cesium grew out of his understanding of the physics of the cell membrane. Where cell mitosis ceases and the life of the cell is short." The quantity of cesium taken up was sufficient to raise the cell to the 8 pH range. Brewer devised a therapy aimed at depriving the cell of glucose and supporting the system with antioxidants and other nutrients. Based on the ready uptake of cesium and rubidium (which cannot carry glucose across the membrane) by the cancer cells, Dr. In his paper The High pH Therapy for Cancer Tests on Mice and Humans, he stated "mass spectrographic and isotope studies have shown that potassium, rubidium, and especially cesium are most efficiently taken up by cancer cells. The development of his theory of high pH cancer therapy with cesium grew out of his understanding of the physics of the cell membrane. It is by this process that the energy required for other vital processes is made available to the cells in a form capable of immediate utilization. The discovery for which the Nobel Prize for Physiology or Medicine is to be awarded today concerns intracellular combustion: that fundamental vital process by which substances directly supplied to cells or stored in them are broken down into simpler components while using up oxygen. No way can be imagined that is scientifically better founded to prevent and cure a disease, the prime cause of which is an impaired respiration. The Prime Cause and Prevention of Cancer.The current popular opinion is that cancer cells ferment glucose while keeping up the same level of respiration that was present before the process of carcinogenesis, and thus the Warburg Effect would be defined as the observation that cancer cells exhibit glycolysis with lactate secretion and mitochondrial respiration even in the presence of oxygen. In other words, instead of fully respiring in the presence of adequate oxygen, cancer cells ferment. The Warburg Effect describes the observation that cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when enough oxygen is present to properly respire. The Warburg Theory of Cancer or "Warburg hypothesis" (as distinguished from the Warburg effect) postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria. Warburg investigated the metabolism of tumors and the respiration of cells, particularly cancer cells, and in 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme." The award came after receiving 46 nominations over a period of nine years beginning in 1923, 13 of which were submitted in 1931, the year he won the prize. Put in his own words, "the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar." Warburg presented evidence in support of the claim that anaerobiosis was a primary cause of cancerous cells. Warburg articulated his hypothesis in a paper entitled The Prime Cause and Prevention of Cancer. In 1944, Warburg was nominated a second time for the Nobel Prize in Physiology or Medicine for his work on the mechanism and enzymes involved in fermentation. Warburg investigated the metabolism of tumors and the respiration of cells, particularly cancer cells, and in 1931 was awarded the Nobel Prize in Physiology or Medicine for his "discovery of the nature and mode of action of the respiratory enzyme". ![]()
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